vitamin K2 MK-4 high dose
Selected indexed studies
- MK-4 Ameliorates Diabetic Osteoporosis in Angiogenesis-Dependent Bone Formation by Promoting Mitophagy in Endothelial Cells. (Drug Des Devel Ther, 2025) [PMID:40160965]
- Maximal dose-response of vitamin-K2 (menaquinone-4) on undercarboxylated osteocalcin in women with osteoporosis. (Int J Vitam Nutr Res, 2020) [PMID:30816822]
- Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women. (J Bone Miner Metab, 2014) [PMID:23702931]
_Worker-drafted node — pending editorial review._
Connections
vitamin K2 MK-4 high dose helps
vitamin K2 MK-4 high dose protects against
Sources
- MK-4 Ameliorates Diabetic Osteoporosis in Angiogenesis-Dependent Bone Formation by Promoting Mitophagy in Endothelial Cells. (2025) pubmed
- Maximal dose-response of vitamin-K2 (menaquinone-4) on undercarboxylated osteocalcin in women with osteoporosis. (2020) pubmed
- Menaquinone 4 Reduces Bone Loss in Ovariectomized Mice through Dual Regulation of Bone Remodeling. (2021) pubmed
- The effect of vitamin K2 on bone metabolism in aged female rats. (2005) pubmed
- Impact of menaquinone-4 supplementation on coronary artery calcification and arterial stiffness: an open label single arm study. (2016) pubmed
- Vitamin K(2)-MK-7 improves nitric oxide-dependent endothelial function in ApoE/LDLR(-/-) mice. (2019) pubmed
- Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women. (2014) pubmed
- Menaquinone-4 Accelerates Calcification of Human Aortic Valve Interstitial Cells in High-Phosphate Medium through PXR. (2020) pubmed
- Menaquinone-4 Suppresses Lipopolysaccharide-Induced Inflammation in MG6 Mouse Microglia-Derived Cells by Inhibiting the NF-κB Signaling Pathway. (2019) pubmed
- Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. (2012) pubmed