V-ATPase lysosomal acidification
Selected indexed studies
- Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease. (Ageing Res Rev, 2016) [PMID:27197071]
- Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes. (Science, 2017) [PMID:29074583]
- Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion. (Autophagy, 2015) [PMID:26156798]
_Worker-drafted node — pending editorial review._
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- Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease. (2016) pubmed
- Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes. (2017) pubmed
- Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion. (2015) pubmed
- Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes. (2022) pubmed
- Lysosomal acidification mechanisms. (2012) pubmed
- Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly. (2022) pubmed
- The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation. (2024) pubmed
- Prosapogenin A induces GSDME-dependent pyroptosis of anaplastic thyroid cancer through vacuolar ATPase activation-mediated lysosomal over-acidification. (2024) pubmed
- Rag GTPases control lysosomal acidification by regulating v-ATPase assembly in Drosophila. (2025) pubmed
- Defective Lamtor5 Leads to Autoimmunity by Deregulating v-ATPase and Lysosomal Acidification. (2024) pubmed