TGR5 bile acid GPCR
Selected indexed studies
- TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy. (Cell Death Dis, 2023) [PMID:37658045]
- Molecular Regulation of Bile Acid Homeostasis. (Drug Metab Dispos, 2022) [PMID:34686523]
- The Critical Role of the Bile Acid Receptor TGR5 in Energy Homeostasis: Insights into Physiology and Therapeutic Potential. (Int J Mol Sci, 2025) [PMID:40724796]
_Worker-drafted node — pending editorial review._
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- TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy. (2023) pubmed
- Molecular Regulation of Bile Acid Homeostasis. (2022) pubmed
- The Critical Role of the Bile Acid Receptor TGR5 in Energy Homeostasis: Insights into Physiology and Therapeutic Potential. (2025) pubmed
- The TGR5 receptor mediates bile acid-induced itch and analgesia. (2013) pubmed
- The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. (2011) pubmed
- A novel TGR5 agonist Sauchinone ameliorates IMQ induced murine psoriasis by regulating macrophage polarization. (2026) pubmed
- The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. (2013) pubmed
- Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism. (2015) pubmed
- The G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Inhibits Gastric Inflammation Through Antagonizing NF-κB Signaling Pathway. (2015) pubmed
- TGR5, Not Only a Metabolic Regulator. (2016) pubmed