Sucralose (added)

Sucralose is an artificial sweetener used in many foods and drinks as a sugar substitute, and its effects on health have been widely studied.

Research indicates that sucralose does not appear to increase cancer risk based on large cohort studies. However, there are concerns about metabolic impacts; long-term use may affect blood glucose levels and insulin responses. Additionally, replacing added sugars with sucralose can alter gut microbiome composition, which might influence overall health. Studies also show that using sucralose in e-cigarettes can lead to toxic emissions.

This additive connects strongly to topics like artificial sweeteners, metabolic health, and gut microbiota. It is also linked to discussions on diet modifications aimed at reducing sugar intake.

The evidence base for some effects of sucralose is still evolving, with more research needed to fully understand long-term impacts.

Sources

• Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study. (PMID:35324894)
• The Effect of Non-Nutritive Sweetened Beverages on Postprandial Glycemic and Endocrine Responses: A Systematic Review and Network Meta-Analysis. (PMID:36839408)
• Long-term metabolic effects of non-nutritive sweeteners. (PMID:38977130)
• Toxic emissions resulting from sucralose added to electronic cigarette liquids. (PMID:36506805)
• Effect of Replacing Added Sugars with Sucralose on Gut Microbiome Composition Among Asian Indian Adults in Two 12-week Randomized Controlled Trials. (PMID:41451263)
• Rationale, Design and Participants Baseline Characteristics of a Crossover Randomized Controlled Trial of the Effect of Replacing SSBs with NSBs versus Water on Glucose Tolerance, Gut Microbiome and Cardiometabolic Risk in Overweight or Obese Adult SSB Consumer: Strategies to Oppose SUGARS with Non-Nutritive Sweeteners or Water (STOP Sugars NOW) Trial and Ectopic Fat Sub-Study. (PMID:36904237)

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