Nrf2 KEAP1 antioxidant
Selected indexed studies
- Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. (Genes Dev, 1999) [PMID:9887101]
- Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling. (Cell Death Dis, 2023) [PMID:38007430]
- Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives. (Biomolecules, 2022) [PMID:36139066]
_Worker-drafted node — pending editorial review._
Connections
No connections recorded yet.
Sources
- Involvement of the Keap1-Nrf2-ARE pathway in the antioxidant activity of sinomenine. (2024) pubmed
- Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. (1999) pubmed
- Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling. (2023) pubmed
- Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives. (2022) pubmed
- The Keap1-Nrf2-antioxidant response element pathway: a review of its regulation by melatonin and the proteasome. (2015) pubmed
- Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy. (2021) pubmed
- Natural products as non-covalent and covalent modulators of the KEAP1/NRF2 pathway exerting antioxidant effects. (2024) pubmed
- Nrf2 signaling in heart failure: expression of Nrf2, Keap1, antioxidant, and detoxification genes in dilated or ischemic cardiomyopathy. (2022) pubmed
- Arsenic-mediated activation of the Nrf2-Keap1 antioxidant pathway. (2013) pubmed
- SIRT7-mediated NRF2 deacetylation promotes antioxidant response and protects against chemodrug-induced liver injury. (2025) pubmed