NR (nicotinamide riboside)

NR, or nicotinamide riboside, is a supplement that serves as a precursor to NAD+, an important molecule involved in energy metabolism and cellular health. Studies indicate that NR can enhance NAD+ levels both in mice and humans, which may contribute to various health benefits. Research has found that NR supplementation helps reduce inflammation and supports muscle mass maintenance. Additionally, it shows potential for protecting against cognitive decline and possibly alleviating depression symptoms. While these findings are promising, the evidence primarily comes from cohort studies and randomized controlled trials with moderate strength, suggesting further research is needed to fully understand its effects.

Sources

• NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health. (PMID:37273100)
• Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD(+) synthesis via enterohepatic circulation. (PMID:40117359)
• The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease. (PMID:35235774)
• Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. (PMID:27721479)
• Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD(+) Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. (PMID:31412242)
• Nicotinamide riboside attenuates myocardial ischemia-reperfusion injury via regulating SIRT3/SOD2 signaling pathway. (PMID:38703508)

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