NMN

Nicotinamide mononucleotide (NMN) is a supplement that has gained attention for its potential to promote health and longevity by supporting cellular function. Clinical trials have demonstrated that NMN supplementation can improve markers of inflammation, oxidative stress, cognitive decline, cardiovascular health, and immune function in middle-aged adults. Long-term studies in mice have shown that NMN treatment can increase both lifespan and healthspan, particularly in a sex-dependent manner.

NMN has been found to help reduce inflammation and oxidative stress, which are key factors in aging and various chronic conditions. It also shows promise in protecting against cognitive decline and cardiovascular disease, while supporting immune function. These effects suggest that NMN may have broad benefits for maintaining overall health as people age.

However, the evidence is primarily from cohort studies with moderate strength, and more robust clinical trials are needed to confirm these findings.

Sources

• Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns. (PMID:35499054)
• The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. (PMID:36482258)
• NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health. (PMID:37273100)
• Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner. (PMID:38979132)
• The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions. (PMID:35441939)
• Biological properties, synthetic pathways and anti-aging mechanisms of nicotinamide mononucleotide (NMN): Research progress and challenges. (PMID:40550930)

_Worker-drafted node, Hermes writer enrichment, pending editorial review._