NAD+ de novo kynurenine
Selected indexed studies
- Macrophage de novo NAD(+) synthesis specifies immune function in aging and inflammation. (Nat Immunol, 2019) [PMID:30478397]
- Kynurenine 3-monooxygenase limits de novo NAD(+) synthesis through dietary tryptophan in renal proximal tubule epithelial cell models. (Am J Physiol Cell Physiol, 2024) [PMID:38497113]
- NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis. (Exp Gerontol, 2020) [PMID:31917996]
_Worker-drafted node — pending editorial review._
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Sources
- Macrophage de novo NAD(+) synthesis specifies immune function in aging and inflammation. (2019) pubmed
- Kynurenine 3-monooxygenase limits de novo NAD(+) synthesis through dietary tryptophan in renal proximal tubule epithelial cell models. (2024) pubmed
- NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis. (2020) pubmed
- Tryptophan and indole metabolism in immune regulation. (2021) pubmed
- De novo NAD(+) synthesis contributes to CD8(+) T cell metabolic fitness and antitumor function. (2023) pubmed
- A Minimal Kynurenine Pathway Was Preserved for Rhodoquinone but Not for De Novo NAD(+) Biosynthesis in Parasitic Worms: The Essential Role of NAD(+) Rescue Pathways. (2024) pubmed
- Uridine monophosphate synthetase enables eukaryotic de novo NAD(+) biosynthesis from quinolinic acid. (2017) pubmed
- Alterations in tryptophan metabolism and de novo NAD(+) biosynthesis within the microbiota-gut-brain axis in chronic intestinal inflammation. (2024) pubmed
- Reprogramming of the kynurenine pathway impairs NAD(+) homeostasis and mediates doxorubicin-induced cardiotoxicity in mice. (2026) pubmed
- Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia-Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis. (2022) pubmed