MTHFR C677T

The MTHFR C677T genetic variant affects how your body processes folate and homocysteine, which can influence several health conditions. Studies indicate that individuals with this variant may have a higher risk of cardiovascular diseases due to altered one-carbon metabolism leading to increased homocysteine levels. There is also evidence linking the MTHFR C677T polymorphism to an elevated risk of certain cancers, including breast cancer and gliomas, though the mechanisms are not fully understood. Additionally, this variant has been associated with male infertility and type 2 diabetes in specific populations. These connections highlight its importance in personalized health assessments. However, it is important to note that while these associations exist, more research is needed to understand the full impact of the MTHFR C677T variant on various health outcomes.

Sources

• Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases. (PMID:25449138)
• Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks. (PMID:34960114)
• MTHFR C677T、MTHFR A1298C、MTRR A66G and MTR A2756G polymorphisms and male infertility risk: a systematic review and meta-analysis. (PMID:39478547)
• MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review. (PMID:33920562)
• Meta-analysis of MTHFR C677T polymorphism and type 2 diabetes mellitus in MENA region. (PMID:38373383)
• Association between MTHFR C677T/A1298C and susceptibility to autism spectrum disorders: a meta-analysis. (PMID:32972375)

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