MOTS-c

MOTS-c is a peptide produced by mitochondria that plays a key role in metabolic health and muscle function.

Research indicates that MOTS-c helps prevent metabolic disorders like obesity and insulin resistance, which are common issues linked to poor diet and lifestyle choices. It does this by promoting metabolic homeostasis and reducing the signals that lead to muscle atrophy. Additionally, studies have found that MOTS-c can suppress ovarian cancer progression by interfering with specific cellular processes.

MOTS-c connects strongly with concepts related to metabolism regulation and muscle health, as well as potential roles in cancer suppression mechanisms.

While promising, the evidence for MOTS-c's effects is based on a relatively small number of studies, primarily in animal models or cell cultures, which limits our understanding of its full impact in humans.

Sources

• MOTS-c Functionally Prevents Metabolic Disorders. (PMID:36677050)
• MOTS-c reduces myostatin and muscle atrophy signaling. (PMID:33554779)
• MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. (PMID:36761202)
• MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus. (PMID:31378979)
• The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. (PMID:25738459)
• Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination. (PMID:39321430)

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