IGF-1/PI3K/AKT pathway
Selected indexed studies
- GLP-2 ameliorates D-galactose induced muscle aging by IGF-1/Pi3k/Akt/FoxO3a signaling pathway in C2C12 cells and mice. (Arch Gerontol Geriatr, 2024) [PMID:38692155]
- The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. (Mol Cell, 2004) [PMID:15125842]
- Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis. (Phytomedicine, 2025) [PMID:41106096]
_Worker-drafted node — pending editorial review._
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Sources
- GLP-2 ameliorates D-galactose induced muscle aging by IGF-1/Pi3k/Akt/FoxO3a signaling pathway in C2C12 cells and mice. (2024) pubmed
- The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. (2004) pubmed
- Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis. (2025) pubmed
- Therapeutic Consequences of Targeting the IGF-1/PI3K/AKT/FOXO3 Axis in Sarcopenia: A Narrative Review. (2023) pubmed
- Mitochondrial dysfunction: roles in skeletal muscle atrophy. (2023) pubmed
- Nutrient weight against sarcopenia: regulation of the IGF-1/PI3K/Akt/FOXO pathway in quinoa metabolites. (2021) pubmed
- Oleanolic Acid Slows Down Aging Through IGF-1 Affecting the PI3K/AKT/mTOR Signaling Pathway. (2025) pubmed
- Dietary carbohydrate-to-protein caloric ratio availability affects hepatic fat deposition via the IGF-1/PI3K/Akt signaling pathway. (2025) pubmed
- Inhibition of the IGF-1-PI3K-Akt-mTORC2 pathway in lipid rafts increases neuronal vulnerability in a genetic lysosomal glycosphingolipidosis. (2019) pubmed
- Wide Pulse Width Electroacupuncture Ameliorates Denervation-Induced Skeletal Muscle Atrophy in Rats via IGF-1/PI3K/Akt Pathway. (2021) pubmed