High-fructose corn syrup (added)
High-fructose corn syrup (HFCS) is a sweetener commonly added to beverages and processed foods, raising concerns about its impact on health. Studies link HFCS consumption with increased risks of obesity, non-alcoholic fatty liver disease, and kidney disease in certain populations. For instance, the consumption of HFCS in beverages has been associated with rising obesity rates, while fructose metabolism is implicated in the development of non-alcoholic fatty liver disease. Additionally, HFCS has been shown to accelerate kidney disease and mortality in obese mice with metabolic syndrome. While these findings highlight potential health risks, the evidence on the direct effects of HFCS remains complex and sometimes controversial. Further research is needed to fully understand the long-term impacts of HFCS consumption on human health.
Sources
- Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. (PMID:15051594)
- Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. (PMID:29408694)
- Molecular aspects of fructose metabolism and metabolic disease. (PMID:34619074)
- Sugar consumption, metabolic disease and obesity: The state of the controversy. (PMID:26376619)
- The Impact of Free Sugar on Human Health-A Narrative Review. (PMID:36839247)
- High Fructose Corn Syrup Accelerates Kidney Disease and Mortality in Obese Mice with Metabolic Syndrome. (PMID:37238651)
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Sources
- Sugar consumption, metabolic disease and obesity: The state of the controversy. (2016) pubmed
- Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. (2004) pubmed
- Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. (2018) pubmed
- Molecular aspects of fructose metabolism and metabolic disease. (2021) pubmed
- The Impact of Free Sugar on Human Health-A Narrative Review. (2023) pubmed
- High Fructose Corn Syrup Accelerates Kidney Disease and Mortality in Obese Mice with Metabolic Syndrome. (2023) pubmed
- The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease. (2016) pubmed
- High-fructose corn syrup promotes proinflammatory Macrophage activation via ROS-mediated NF-κB signaling and exacerbates colitis in mice. (2022) pubmed
- Sugar in Infants, Children and Adolescents: A Position Paper of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. (2017) pubmed
- The Impact of Free and Added Sugars on Cognitive Function: A Systematic Review and Meta-Analysis. (2023) pubmed