heme biosynthesis ALAS1
Selected indexed studies
- Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing. (Science, 2024) [PMID:39700288]
- Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis. (Sci Signal, 2022) [PMID:36318618]
- Update on heme biosynthesis, tissue-specific regulation, heme transport, relation to iron metabolism and cellular energy. (Liver Int, 2024) [PMID:38888238]
_Worker-drafted node — pending editorial review._
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- Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing. (2024) pubmed
- Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis. (2022) pubmed
- Update on heme biosynthesis, tissue-specific regulation, heme transport, relation to iron metabolism and cellular energy. (2024) pubmed
- Peroxisome proliferator-activated receptor alpha controls hepatic heme biosynthesis through ALAS1. (2009) pubmed
- Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis. (2016) pubmed
- Heme Biosynthesis is Crucial for Cell Survival and Mitochondrial OXPHOS after X Irradiation. (2024) pubmed
- Effects of Doxorubicin on Heme Biosynthesis and Metabolism in Cardiomyocyte. (2021) pubmed
- Flvcr1a deficiency promotes heme-based energy metabolism dysfunction in skeletal muscle. (2024) pubmed
- The novel heme-dependent inducible protein, SRRD regulates heme biosynthesis and circadian rhythms. (2017) pubmed
- Heme-dependent recognition of 5-aminolevulinate synthase by the human mitochondrial molecular chaperone ClpX. (2021) pubmed