Fisetin

Fisetin is a plant compound that shows promise in combating age-related diseases and improving overall health.

Research indicates that fisetin can act as a senotherapeutic agent, which means it helps to reduce cellular aging by targeting senescent cells. This effect has been linked to improvements in health and lifespan. Additionally, studies have shown that fisetin can ameliorate kidney disease and cognitive impairment by inhibiting inflammation and promoting cell repair processes like mitophagy.

Fisetin is notably connected to helping with oxidative stress and protecting against cardiovascular disease. It also supports bone density and may help protect against cognitive decline, making it a potential supplement for maintaining health as one ages.

While the evidence is promising, most studies are based on animal models or in vitro experiments, so human benefits need further investigation.

Sources

• Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases. (PMID:39384074)
• Fisetin is a senotherapeutic that extends health and lifespan. (PMID:30279143)
• Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis. (PMID:37696989)
• Fisetin: hormesis accounts for many of its chemoprotective effects. (PMID:40208387)
• Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis-associated encephalopathy. (PMID:34837343)
• Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence. (PMID:38062873)

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