Fasting-mimicking diet

A fasting-mimicking diet (FMD) is a type of low-calorie eating plan that mimics the effects of prolonged fasting without actual starvation, and it has gained attention for its potential health benefits and therapeutic uses in treating various diseases. Studies have found that FMD can help reshape metabolism and boost antitumor immunity in cancer patients, potentially aiding in cancer regression when combined with other treatments like hormone therapy or chemotherapy. Additionally, FMD has been linked to improvements in markers related to aging, diabetes, cardiovascular disease, and even the gut microbiome. Connections show that FMD may contribute to longevity and protect against cardiovascular disease by improving metabolic health and promoting a more diverse gut microbiome. While promising, evidence for these effects is based on cohort studies with moderate strength, indicating further research is needed to fully understand its long-term impacts and mechanisms.

Sources

• Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence. (PMID:39059383)
• Fasting-mimicking diet and hormone therapy induce breast cancer regression. (PMID:32669709)
• Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer. (PMID:34789537)
• Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. (PMID:28202779)
• Fasting-mimicking diet-enriched Bifidobacterium pseudolongum suppresses colorectal cancer by inducing memory CD8(+) T cells. (PMID:39870395)
• Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape. (PMID:34731655)

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