cholesterol synthesis HMG-CoA reductase mevalonate
Selected indexed studies
- Regulation of the mevalonate pathway. (Nature, 1990) [PMID:1967820]
- Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol. (Annu Rev Biochem, 2021) [PMID:34153214]
- Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase. (Crit Rev Biochem Mol Biol, 2010) [PMID:20482385]
_Worker-drafted node — pending editorial review._
Connections
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Sources
- Regulation of the mevalonate pathway. (1990) pubmed
- Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol. (2021) pubmed
- Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase. (2010) pubmed
- Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase. (2008) pubmed
- HMG-CoA Reductase as Target for Drug Development. (2020) pubmed
- The structure of the catalytic portion of human HMG-CoA reductase. (2000) pubmed
- Immunomodulatory effects of HMG-CoA reductase inhibitors. (2003) pubmed
- Peroxisomal Localization of a Truncated HMG-CoA Reductase under Low Cholesterol Conditions. (2024) pubmed
- Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. (1980) pubmed
- Green and black tea extracts inhibit HMG-CoA reductase and activate AMP kinase to decrease cholesterol synthesis in hepatoma cells. (2009) pubmed