cholesterol biosynthesis HMG-CoA reductase
Selected indexed studies
- Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis. (Nature, 2020) [PMID:33177714]
- Physiological feedback regulation of cholesterol biosynthesis: Role of translational control of hepatic HMG-CoA reductase and possible involvement of oxylanosterols. (Biochim Biophys Acta, 2015) [PMID:25701719]
- Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol. (Annu Rev Biochem, 2021) [PMID:34153214]
_Worker-drafted node — pending editorial review._
Connections
No connections recorded yet.
Sources
- Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol. (2021) pubmed
- Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase. (2008) pubmed
- HMG-CoA Reductase as Target for Drug Development. (2020) pubmed
- Peroxisomal Localization of a Truncated HMG-CoA Reductase under Low Cholesterol Conditions. (2024) pubmed
- Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis. (2020) pubmed
- Physiological feedback regulation of cholesterol biosynthesis: Role of translational control of hepatic HMG-CoA reductase and possible involvement of oxylanosterols. (2015) pubmed
- Post-Translational Regulation of HMG CoA Reductase. (2022) pubmed
- HMG-CoA reductase inhibitors. (1985) pubmed
- Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol. (2022) pubmed
- Srebf and Runx3 regulate hepatic HMG-CoA reductase and intracellular cholesterol under hypoxia. (2025) pubmed